Product Description.:
Ointment , translucent , clear
Colorless to light yellow
ATROPINE SULFATE Injection, USP
0.1 mg/mI (Adult)
0.05 mg/mL (Pediatric)
ABBOJECT? Unit of Use Syringe
Atropine Sulfate Injection, USP is a sterile, nonpyrogenic isotonic solution of atropine sulfate monohydrate in water for injection with sodium chloride sufficient to render the solution isotonic. It is administered parenterally by subcutaneous, intramuscular or intravenous injection.
Each milliliter (mL) contains atropine sulfate, monohydrate 0.1 mg (adult strength) or 0.05 mg (pediatric strength), and sodium chloride, 9 mg. May contain sodium hydroxide and/or sulfuric acid for pH adjustment 0.308 mOsmol/mL (calc.). pH 4.2 (3.0 to 6.5).
The solution contains no bacteriostat, antimicrobial agent or added buffer (except for pH adjustment) and is intended for use only as a single-dose injection. When smaller doses are required the unused portion should be discarded.
Atropine Sulfate Injection is a parenteral anticholinergic agent and muscarinic antagonist.
INDICATIONS
Atropine Sulfate Injections, USP, is indicated when excessive (or sometime normal) muscarinic effects are judged to be life threatening or are producing symptoms sever enough to call of temporary, reversible muscarinic blockade. Examples, not an exhaustive list, of such possible uses are:
1. As an antisialogogue when reduction of secretions of the respiratory tract are thought to be needed its routine use as a preanesthetic agent is discouraged
2. To blunt the increased vagal tone (decreased pulse and blood pressure) produced by intra-abdominal tract or ocular muscle traction, its routine use to prevent such events is discouraged
3. To temporarily increase heart rate or decrease AV-block until definitive intervention can take place, when bradycardia or AV-block are judged to be hemodynamically significant and thought to be due to excess vagal tone
4. As an antidote for inadvertent overdose of cholinergic drugs or for cholinesterase poisoning such as from organophosphorus insecticides
5. As an antidote for the rapid type of mushroom poisoning due to the presence of the alkaloid muscarine, in certain species of fungus such as Amanita muscaria, and 6. To alleviate the muscarinic side effects of anticholinesterase drugs used for reversal of neuromuscular blockade
DOSAGE AND ADMINISTRATION
Atropine Sulfate Injection, USP in Ansyr Syringe is intended fo rintravenous use, but may be administered subcutaneously or intramuscularly. Its use usually requires titration, using heart rate, PR interval, blook pressure and/or patient's symptoms as a guide for having reached an appropriate dose.
