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Acuvail Opth Pf 0.45% Drops 30 By Allergan Inc.

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Acuvail Opth Pf 0.45% Drops 30 By Allergan Inc.

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Acuvail Opth Pf 0.45% Drops 30 By Allergan Inc. This Item Requires A Valid Order From A Physician Licensed in USA. Item Number.:RXD4240651/RXB10036007/RXA601228. Size : 30
Selling UoM : EA
NDC: 00023-3507-30
UPC Barcode : 300233507308
Supplier: 0050001063 ALLERGAN USA, INC.
Supplier Material : 93507
Generic Code : 065413 KETOROLAC TROMETHAMINE/PF OPHTHALMIC DRO
Fine Line Class : 850085008510 All Rx Products
Product Category : RX Pharmaceuticals
Product Type : BRX Branded

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Product Description.:

ACUVAIL is formulated at pH 6.8, enabling deionized drug delivery on the corneal surface. ACUVAIL? contains carboxymethylcellulose (CMC), a viscous molecule also found in Allergan's REFRESH? Brand Tears that enables the drug to adhere to the ocular surface and enhances patient comfort.

With ACUVAIL?, patients benefit from the drug's comprehensive inhibition of the COX-1 and COX-2 enzymes. Studies show that those enzymes should be blocked in order to inhibit the development of prostaglandins, which are considered to be the primary sources of pain and inflammation following cataract surgery.

Building on Allergan's 60-year expertise in eye care, we are pleased to provide physicians and their patients with an advanced and effective NSAID option for the treatment of pain and inflammation following cataract surgery, said Scott Whitcup, M.D., Allergan's Executive Vice President, Research and Development and Chief Scientific Officer. With its preservative-free formulation, optimized tolerability and twice-daily dosing convenience, we anticipate that ACUVAIL? will be a valuable addition to the overall management of cataract surgery patients.

The efficacy of ACUVAIL? ophthalmic solution was assessed in two multi-center, randomized, double-masked, parallel group comparison studies involving more than 500 patients receiving either ACUVAIL? or vehicle. In the clinical studies, the efficacy of ACUVAIL? was defined as complete clearance of anterior chamber inflammation measured by summed inflammation score (SOIS) and ocular pain relief following cataract extraction with posterior chamber intraocular lens (IOL) implantation. Results of these studies demonstrated that at day seven, nearly twice as many patients receiving ACUVAIL? solution had an SOIS score of zero when compared to patients treated with vehicle (32 percent versus 17 percent). In addition, patients were shown to have a significantly higher incidence of clearing of anterior chamber inflammation at day 14 versus patients receiving vehicle (53 percent versus 26 percent). ACUVAIL? was also shown to be significantly superior to vehicle in resolving ocular pain post-cataract surgery. On day one post-cataract surgery, the percentage of ACUVAIL? patients with pain scores of zero was 72 percent, compared to 40 percent for patients in the vehicle group.

As an ophthalmic surgeon, I rely on effective therapies that provide my patients with an optimal experience and improve visual outcomes, said Eric Donnenfeld, M.D., F.A.C.S., Ophthalmic Consultants of Long Island. ACUVAIL? is an enhanced ketorolac compound and the first preservative-free, twice-daily ophthalmic NSAID that demonstrates complete elimination of inflammation for patients undergoing cataract surgery.

ACUVAIL? is expected to be available to physicians and patients in the United States in September 2009.

About Cataracts

Cataracts are a leading cause of blindness among older adults in the United States. The exact cause of cataracts is unknown. Most often, cataracts are part of the aging process. As people age, they are at greater risk of developing a cataract. More than 20 million Americans age 40 and older have cataracts and more than half of all Americans have cataracts by the time they are 80 years old.

A cataract is a clouding of the eye's lens, which blocks or changes the passage of light into the eye. The lens of the eye is located behind the pupil and the colored iris, and is normally transparent. The lens helps to focus images onto the retina - which transmits the images to the brain. A person's vision may become blurry or dim because the cataract stops light from properly passing through to the retina.

Risk factors for cataracts include intense heat or long-term exposure to UV rays from the sun certain diseases, such as diabetes inflammation in the eye hereditary influences events before birth, such as German measles in the mother long-term steroid use eye injuries eye diseases and smoking.

Although stronger eyeglasses or brighter lighting may help relieve symptoms of a cataract in the early stages, surgery is the only cure and the most common form of treatment. Cataract surgery is the most frequently performed surgical procedure in the United States, with more than 3 million procedures performed each year. Typically covered by medical insurance, including Medicare, the surgery is usually done as an outpatient procedure under local anesthesia. The procedure consists of an ophthalmologist making a tiny incision to remove the cloudy lens and replacing it with a permanent artificial lens.