Product Description.:
5 220
tablet , white , round round
Flat-faced beveled-edgeDebossedWhite to off-white
DRUG INTERACTIONS:Thyroid hormone affects the body's handling of many drugs. Generally, hypothyroidism (decreased concentration of thyroid hormone) reduces the effects of the body on drugs (metabolism of drugs) while hyperthyroidism (increased concentration of thyroid hormone) increases the effects. Therefore, individuals who are hypothyroid will eliminate drugs more slowly and those with hyperthyroidism will eliminate drugs faster compared with individuals with normal levels of thyroid hormone. This principle also applies to the metabolism of drugs that must be metabolized (changed) by the body into their active forms in order to have an effect. Therefore, liothyronine and other thyroid hormones may change the action of many drugs.
The elimination of theophylline (Theo-Dur) and similar drugs increases as the dose of thyroid hormone increases. Individuals who are hypothyroid have slower theophylline elimination. Therefore, when the concentration of thyroid hormone is returned to normal with liothyronine, the elimination of theophylline is increased. This reduces the concentration of theophylline in the body and can reduce the effectiveness of theophylline. Patients who are treated for thyroid conditions should have their blood concentration of theophylline monitored, and doses of theophylline should be adjusted as necessary.
The administration of liothyronine increases the action of the blood thinning drug, warfarin (Coumadin). Warfarin acts by reducing the concentration of factors in the body that are necessary for blood to clot. The concentration of these clotting factors in the body is determined by the body's rate of metabolism. In theory, by increasing the body's metabolism (elimination) of these clotting factors, thyroid hormones reduce the body's ability to clot and therefore enhance the effects of warfarin. Since this can lead to excessive bleeding, the dose of warfarin may need to be reduced.
Digoxin (Lanoxin) is a drug that is used to control heart rate. Individuals with hypothyroidism tend to be more sensitive (respond more) to digoxin, and, conversely, individuals with hyperthyroidism are less responsive to digoxin. Therefore, increasing the level of thyroid hormone in the body may warrant an increase in the dose of digoxin. The mechanism for this interaction is not clear, but it may involve changes in the absorption of digoxin, digoxin metabolism, or the effects of thyroid hormone on the heart
SIDE EFFECTS: Liothyronine therapy generally is well-tolerated. If symptoms occur, they usually occur because there are toxic (too high) levels of thyroid hormone (hyperthyroidism). Symptoms of hyperthyroidism include: chest pain, increased heart rate, cardiac arrest, excessive sweating, heat intolerance, nervousness, headache, tremor, insomnia, diarrhea, vomiting, weight loss, or fever. Women also may experience irregular menstrual cycles.
Since thyroid hormone affects heart rate and metabolism, the impact of treatment of thyroid hormone on the control of diseases such as atrial fibrillation, diabetes and high cholesterol levels always should be considered.