Product Description.:
Suspension , off-white , pine-coconut mint
STORAGE: Capsules should be kept at room temperature 15-30 C (59-86 F). Oral suspension and suppositories should be kept below 30 C (86 F). The oral suspension should not be frozen.
PRESCRIBED FOR: Indomethacin is used for the treatment of inflammation caused by rheumatoid arthritis, ankylosing spondylitis, gouty arthritis, osteoarthritis, and soft tissue injuries such as tendinitis and bursitis.
DOSING: The recommended dose for adults is 50-200 mg per day split into 2-3 doses. Indomethacin should be taken with food in order to reduce abdominal discomfort.
DRUG INTERACTIONS: Cholestyramine (Questran) and colestipol (Colestid) may decrease the absorption of indomethacin by binding to indomethacin in the intestine and preventing absorption into the body. Indomethacin and other NSAIDs may decrease the elimination of lithium (Eskalith, Lithobid) by the kidneys and, therefore, increase the blood level of lithium, which could lead to lithium toxicity.
Indomethacin may reduce the blood pressure-lowering effects of drugs that are given to reduce blood pressure. This may occur because prostaglandins play a role in the regulation of blood pressure. When indomethacin is used in combination with aminoglycoside antibiotics (for example, gentamicin) the blood levels of the aminoglycoside may increase, presumably because the elimination of aminoglycoside from the body is reduced. This may lead to aminoglycoside-related side effects.
Individuals taking oral blood thinners or anticoagulants [for example, warfarin (Coumadin)] should avoid indomethacin because indomethacin also thins the blood, and excessive blood thinning may lead to bleeding.
PREGNANCY: Use during pregnancy has not been adequately studied. Indomethacin may have adverse effects on the fetus.
NURSING MOTHERS: Indomethacin is excreted in breast milk and therefore should be avoided by nursing mothers.
SIDE EFFECTS: The most common side effects are nausea, vomiting, diarrhea, stomach discomfort, heartburn, rash, headache, dizziness and drowsiness.
Indomethacin may cause or worsen stomach or intestinal bleeding or ulcers. It may lead to perforation of the intestine.
NSAIDs reduce the ability of blood to clot and therefore increase bleeding after an injury.
Indomethacin may cause ulceration of the stomach or intestine, and the ulcers may bleed. Sometimes, ulceration and bleeding can occur without abdominal pain, and black tarry stools, weakness, and dizziness upon standing (orthostatic hypotension) may be the only signs of a ulceration.
NSAIDs reduce the flow of blood to the kidneys and impair function of the kidneys. The impairment is most likely to occur in patients with preexisting impairment of kidney function or congestive heart failure, and use of NSAIDs in these patients should be done cautiously.
Individuals who have nasal polyps or are allergic to aspirin or other NSAIDs should not use indomethacin because there is an increased risk of severe allergic reactions in these individuals.
Fluid retention, blood clots, heart attacks, hypertension (high blood pressure), and heart failure have also been associated with the use of NSAIDs.
