N 343, 2.5
tablet , peach , scored , round round
Compare To: Micronase? and DiaBeta?
STORAGE: Glyburide should be stored at room temperature, 15-30 C (59-86 F).
PRESCRIBED FOR: Glyburide is used in combination with diet and exercise to reduce blood glucose in patients with type 2 diabetes. It may be used alone or combined with other medications for treating type 2 diabetes.
DOSING: The recommended starting dose is 2.5 to 5 mg daily of regular tablets or 1.5-3 mg daily of micronized tablets. The maximum dose is 1.25 to 20 mg of regular tablets and 0.75 to 12 mg of micronized tablets. Glyburide usually is administered with the first main meal of the day.
DRUG INTERACTIONS: Bosentan (Tracleer) and glyburide should not be used together because blood levels of both drugs decrease, potentially reducing their effect, and there is an increase in liver toxicity. Bosentan may increase the breakdown of glyburide in the liver.
There have been reports of changes in blood sugar (increase or decrease) in patients treated with fluoroquinolone type antibiotics, for example, levofloxacin (Levaquin) and ciprofloxacin (Cipro) and antidiabetic agents such as glyburide.
Thiazide diuretics, for example, hydrochlorothiazide (Hydrodiuril) increase blood glucose levels, reducing the effect of glucose reducing medications such as glyburide.
PREGNANCY: There are no adequate studies of glyburide in pregnant women. Prolonged and severe hypoglycemia (low blood glucose) has occurred in infants whose mothers were receiving other sulfonylurea drugs.
NURSING MOTHERS: It is not known whether glyburide is excreted in breast milk. Since many sulfonylureas are excreted in breast milk and potentially may harm the infant, alternative diabetic therapies should be considered or breast feeding should be discontinued.
SIDE EFFECTS: Common side effects include nausea, heartburn, rashes, low blood sugar, blurred vision and weight gain. Rare but serious side effects include hepatitis, jaundice, and low blood sodium levels (hyponatremia).
USES: Glyburide is an anti-diabetic drug (sulfonylurea-type) used along with a proper diet and exercise program to control high blood sugar. It is used in patients with type 2 diabetes (non-insulin-dependent diabetes). It works by stimulating the release of your body's natural insulin. Effectively controlling high blood sugar helps prevent heart disease, strokes, kidney disease, blindness, and circulation problems, as well as sexual function problems (impotence).
HOW TO USE: Take this medication by mouth with breakfast or the first main meal, usually once daily or use as directed by your doctor. Some patients, especially those taking higher doses, may be directed to take this drug twice a day. The dosage is based on your medical condition and response to therapy. Use this medication regularly in order to get the most benefit from it. To help you remember, use it at the same time(s) each day. Monitor blood glucose levels on a regular basis.
SIDE EFFECTS: Nausea, heartburn, stomach fullness, and weight gain may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: persistent sore throat or fever, easy bleeding or bruising, stomach pain, yellowing eyes or skin, dark urine, unusual tiredness or weakness, unusual or sudden weight gain, mental/mood changes, swelling of the hands or feet, seizures. This medication can cause low blood sugar (hypoglycemia). This effect may occur if you do not consume enough calories (from food, juices, fruit, etc.). The symptoms include chills, cold sweat, blurred vision, dizziness, drowsiness, shaking, rapid heart rate, weakness, headache, fainting, tingling of the hands or feet, or hunger. It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you are in a situation where you don't have these reliable forms of glucose, eat a quick source of sugar such as table sugar, honey, or candy, or drink a glass of orange juice or non-diet soda to quickly raise your blood sugar level. Tell your doctor immediately about the reaction. To help prevent hypoglycemia, eat meals on a regular schedule and do not skip meals. Symptoms of high blood sugar (hyperglycemia) include thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, or fruity breath odor. If these symptoms occur, tell your doctor immediately. Your medication dosage may need to be increased. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.
PRECAUTIONS: This medication should not be used if you have certain medical conditions.