DESCRIPTION
Cordran? (Flurandrenolide, USP) is a potent corticosteroid intended for topical use. Flurandrenolide occurs as white to off-white, fluffy, crystalline powder and is odorless. Flurandrenolide is practically insoluble in water and in ether. One g dissolves in 72 mL of alcohol and in 10 mL of chloroform. The molecular weight of flurandrenolide is 436.52.
Each g of Cordran? SP Cream (Flurandrenolide Cream, USP) contains 0.5 mg (1.145 μmol 0.05%) or 0.25 mg (0.57 μmol 0.025%) flurandrenolide in an emulsified base composed of cetyl alcohol, citric acid, mineral oil, polyoxyl 40 stearate, propylene glycol, sodium citrate, stearic acid, and purified water.
Each g of Cordran? Ointment (Flurandrenolide Ointment, USP) contains 0.5 mg (1.145 μmol 0.05%) or 0.25 mg (0.57 μmol 0.025%) flurandrenolide in a base composed of white wax, cetyl alcohol, sorbitan sesquioleate, and white petrolatum.
INDICATIONS
Cordran is indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
SIDE EFFECTS
The following local adverse reactions are reported infrequently with topical corticosteroids but may occur more frequently with the use of occlusive dressings. These reactions are listed in an approximate decreasing order of occurrence:
Burning
Itching
Irritation
Dryness
Folliculitis
Hypertrichosis
Acneform eruptions
Hypopigmentation
Perioral dermatitis
Allergic contact dermatitis
The following may occur more frequently with occlusive dressings:
Maceration of the skin
Secondary infection
Skin atrophy
Striae
Miliaria
