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Demadex 10mg Tablets 1X100 Each By Meda Pharmaceuticals Inc

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Demadex 10mg Tablets 1X100 Each By Meda Pharmaceuticals Inc

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Demadex 10mg Tablets 1X100 Each By Meda Pharmaceuticals Inc Item No.:This Item Requires A Valid Order From A Physician Licensed in USA. RXD4160396/RXB10019687 UPC No.: 300375010018 Mfg.Part No.:455101 Item Profile
Cin 4160396
Ndc 00037501001
Generic Name Torsemide
Trade Name Demadex
Additional Description
Strength 10Mg
Form Tabs
Size 100 Ea
Unit Of Measure Ea
Unit Of Sale Ea
Unit Dose
Schedule No. 0
Private Label 999
Multi-Source Y
Active Status Activ

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DEMADEX?
(torsemide) Tablets & Injection
DRUG DESCRIPTION

DEMADEX (torsemide) is a diuretic of the pyridine-sulfonylurea class.

Torsemide is a white to off-white crystalline powder. The tablets for oral administration also contain lactose NF, crospovidone NF, povidone USP, microcrystalline cellulose NF, and magnesium stearate NF. Torsemide ampuls for intravenous injection contain a sterile solution of torsemide (10 mg/mL), polyethylene glycol-400 NF, tromethamine USP, and sodium hydroxide NF (as needed to adjust pH) in water for injection USP.

INDICATIONS

DEMADEX is indicated for the treatment of edema associated with congestive heart failure, renal disease, or hepatic disease. Use of torsemide has been found to be effective for the treatment of edema associated with chronic renal failure. Chronic use of any diuretic in hepatic disease has not been studied in adequate and well-controlled trials.

DEMADEX intravenous injection is indicated when a rapid onset of diuresis is desired or when oral administration is impractical.

DEMADEX is indicated for the treatment of hypertension alone or in combination with other antihypertensive agents.

SIDE EFFECTS

At the time of approval, DEMADEX had been evaluated for safety in approximately 4000 subjects: over 800 of these subjects received DEMADEX for at least 6 months, and over 380 were treated for more than 1 year. Among these subjects were 564 who received DEMADEX during United States-based trials in which 274 other subjects received placebo.

The reported side effects of DEMADEX were generally transient, and there was no relationship between side effects and age, sex, race, or duration of therapy. Discontinuation of therapy due to side effects occurred in 3.5% of United States patients treated with DEMADEX and in 4.4% of patients treated with placebo. In studies conducted in the United States and Europe, discontinuation rates due to side effects were 3.0% (38/1250) with DEMADEX and 3.4% (13/380) with furosemide in patients with congestive heart failure, 2.0% (8/409) with DEMADEX and 4.8% (11/230) with furosemide in patients with renal insufficiency, and 7.6% (13/170) with DEMADEX and 0% (0/33) with furosemide in patients with cirrhosis.

The most common reasons for discontinuation of therapy with DEMADEX were (in descending order of frequency) dizziness, headache, nausea, weakness, vomiting, hyperglycemia, excessive urination, hyperuricemia, hypokalemia, excessive thirst, hypovolemia, impotence, esophageal hemorrhage, and dyspepsia. Dropout rates for these adverse events ranged from 0.1% to 0.5%.