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Avapro 75mg Tablets 1X30 Each Unit Dose Package By Bristol Primary Care Product

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Avapro 75mg Tablets 1X30 Each Unit Dose Package By Bristol Primary Care Product

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Avapro 75mg Tablets 1X30 Each Unit Dose Package By Bristol Primary Care Product Item No.:This Item Requires A Valid Order From A Physician Licensed in USA. RXD2701068/RXB10113456 Avapro 75mg Tablets 1X30 Each Mfg.By: Bristol Primary Care Product USA. Unit Dose Package This Item Requires A Valid Order From A Physician Licensed in The USA. Item No.:RXD2701068 NDC No.: 00087-2771-31 Category: Irbesartan Compare To:
UPC No.: 300872771313 Mfg.Part No.:277131

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INDICATIONS
AVAPRO (irbesartan) is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents.

AVAPRO is also indicated for the treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (>300 mg/day) in patients with type 2 diabetes and hypertension. In this population, AVAPRO reduces the rate of progression of nephropathy as measured by the occurrence of doubling of serum creatinine or end-stage renal disease (need for dialysis or renal transplantation).
AVALIDE (irbesartan-hydrochlorothiazide) is indicated for the treatment of hypertension.

AVALIDE may be used in patients whose blood pressure is not adequately controlled on monotherapy.

AVALIDE may also be used as initial therapy in patients who are likely to need multiple drugs to achieve their blood pressure goals.

The choice of AVALIDE as initial therapy for hypertension should be based on an assessment of potential benefits and risks and this decision should be shaped by considerations such as baseline blood pressure, target goal, and likelihood of achieving goal compared to monotherapy.

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IMPORTANT SAFETY INFORMATION
WARNING: USE IN PREGNANCY
When pregnancy is detected, discontinue AVAPRO or AVALIDE as soon as possible. When used in pregnancy during the second and third trimesters, drugs that act directly on the renin-angiotensin system can cause injury and even death to the developing fetus. [See Warnings and Precautions: Fetal/Neonatal Morbidity and Mortality in the full Prescribing Information.]

* Because of the hydrochlorothiazide component, AVALIDE is contraindicated in patients with anuria or hypersensitivity to sulfonamide-derived drugs
* In patients with volume or sodium depletion (eg, patients vigorously treated with diuretics or on dialysis), such depletion should be corrected prior to administration of AVAPRO or AVALIDE, or a lower initial dose of AVAPRO (75 mg) should be used, to avoid possible symptomatic hypotension
* Hypersensitivity reactions to hydrochlorothiazide may occur in patients with or without a history of allergy or bronchial asthma, but are more likely in patients with such a history
* Thiazide diuretics have been reported to cause exacerbation or activation of systemic lupus erythematosus
* Lithium generally should not be given with thiazides
* Thiazides should be used with caution in patients with severe renal disease and in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma
* In placebo-controlled hypertension studies, there were no significant differences in adverse events (AEs) between AVAPRO and placebo. Adverse events that occurred in at least 1% of patients treated with AVAPRO and at a higher incidence vs placebo included diarrhea (3% vs 2%), dyspepsia/heartburn (2% vs 1%) and
fatigue (4% vs 3%)
* Additionally, in a study of hypertensive type 2 diabetic patients with renal disease (proteinuria � mg/day), the reported AEs for AVAPRO were similar to those seen in hypertension studies, with the exception of an increased incidence of orthostatic symptoms AVAPRO compared to placebo (both groups received adjunctive antihypertensives): dizziness (10.2% vs 6.0%), orthostatic dizziness (5.4% vs 2.7%) and orthostatic hypotension (5.4% vs 3.2%), respectively. In patients with proteinuria, monitor serum potassium
* In placebo-controlled hypertension studies, the most common adverse experiences reported with AVALIDE that occurred in ��% of patients and at a higher incidence vs placebo included fatigue (7% vs 3%), musculoskeletal pain (7% vs 5%), dizziness (8% vs 4%), and nausea/vomiting (3% vs 0%). In a study with AVALIDE used as initial therapy in moderate hypertension, the most common incidences of pre-specified adverse experiences reported that occurred in ��% of patients were: dizziness (3.0%, 3.8% and 1.0%), headache (5.5%, 3.8% and 4.8%) and hyperkalemia (1.2%, 0% and 1.0%) in AVALIDE, AVAPRO and HCTZ, respectively. In a study with AVALIDE used as initial therapy in severe hypertension, the most common incidences of pre-specified adverse experiences reported that occurred in ��% were: dizziness (3.6% and 4.0%) and headache (4.3% and 6.6%) in AVALIDE and AVAPRO, respectively